Gamma-sarcoglycan is a protein that is part of the sarcoglycan complex, which plays a crucial role in maintaining the structural integrity of muscle cells. It is primarily found in skeletal and cardiac muscles, where it helps connect the cell membrane to the underlying cytoskeleton. This connection is essential for muscle function and stability during contraction. Mutations in the gene encoding gamma-sarcoglycan can lead to sarcoglycanopathies, a group of genetic disorders that cause muscle weakness and degeneration. One common condition associated with gamma-sarcoglycan mutations is limb-girdle muscular dystrophy type 2C, which affects mobility and overall muscle health.