Familial partial lipodystrophy is a rare genetic disorder characterized by the loss of fat tissue in specific areas of the body, often affecting the limbs and face. This condition can lead to an abnormal distribution of body fat, resulting in a more pronounced appearance of fat in other areas, such as the abdomen. Individuals with familial partial lipodystrophy may also experience metabolic complications, including insulin resistance and an increased risk of type 2 diabetes and cardiovascular disease. The condition is often inherited in an autosomal dominant pattern, meaning that only one copy of the mutated gene from an affected parent can cause the disorder in their offspring.