Cryogenic electron microscopy (cryo-EM) is a powerful imaging technique used to visualize biological samples at very low temperatures. By rapidly freezing samples, cryo-EM preserves their natural structure, allowing scientists to study proteins, viruses, and other complex molecules in their native state without the need for crystallization. This method involves using an electron microscope to capture high-resolution images of the frozen samples. The resulting images can be combined to create three-dimensional models, providing valuable insights into molecular structures and functions, which is crucial for advancements in fields like biochemistry and drug development.