Zinc-dependent metalloproteinases are enzymes that require zinc ions to function properly. They play a crucial role in breaking down proteins by cleaving peptide bonds. These enzymes are involved in various biological processes, including tissue remodeling, wound healing, and the immune response. These metalloproteinases are classified into several families, with the most well-known being the matrix metalloproteinases (MMPs). MMPs are essential for maintaining the extracellular matrix and are implicated in various diseases, such as cancer and arthritis. Their activity is tightly regulated to ensure proper physiological function and prevent tissue damage.