Vitis rotundifolia, commonly known as the muscadine grape, is a species of grape native to the southeastern United States. It is characterized by its round leaves and thick-skinned, sweet grapes that come in various colors, including purple, bronze, and black. Muscadine grapes are well-suited to warm climates and are often grown in vineyards for wine production and fresh consumption. This grape species is notable for its high resistance to diseases and pests, making it easier to cultivate than other grape varieties. Vitis rotundifolia is also rich in antioxidants and has been studied for its potential health benefits, including anti-inflammatory properties.