UDP-glucuronosyltransferases (UGTs) are a family of enzymes that play a crucial role in the metabolism of various substances in the body. They facilitate the process of glucuronidation, where a glucuronic acid molecule is added to a compound, making it more water-soluble. This modification helps in the detoxification and elimination of drugs, hormones, and other metabolites from the body. These enzymes are primarily found in the liver but are also present in other tissues. UGTs are important for drug metabolism, influencing how long a drug remains active in the body and its overall effectiveness. Variations in UGT activity can affect individual responses to medications.