Phase II metabolism is a biochemical process where the body modifies substances to make them more water-soluble. This phase typically involves the conjugation of drugs or toxins with endogenous molecules, such as glucuronic acid, sulfate, or glutathione. This modification helps facilitate the excretion of these substances through urine or bile. This phase follows Phase I metabolism, which often involves oxidation or reduction reactions. Phase II reactions are crucial for detoxifying drugs, environmental chemicals, and other xenobiotics, ensuring that they are less harmful and easier for the body to eliminate.