Glucuronidation is a biochemical process where a molecule called glucuronic acid is added to a substance, typically a drug or toxin. This reaction is primarily facilitated by enzymes known as UDP-glucuronosyltransferases (UGTs). The addition of glucuronic acid makes the substance more water-soluble, which helps the body eliminate it through urine or bile. This process is crucial for detoxifying various compounds, including medications and environmental toxins. By converting lipophilic substances into hydrophilic forms, glucuronidation enhances their excretion and reduces potential toxicity, playing a vital role in drug metabolism and overall health.