UDP-Glucuronosyltransferase (UGT) is an enzyme that plays a crucial role in the metabolism of various substances in the body. It helps in the process of glucuronidation, where a glucuronic acid molecule is added to drugs, toxins, and other compounds. This modification makes these substances more water-soluble, facilitating their excretion from the body through urine or bile. There are several isoforms of UGT, each responsible for processing different substrates, including medications and hormones. Variations in UGT activity can influence how individuals respond to certain drugs, impacting their effectiveness and potential side effects. Understanding UGT is essential for personalized medicine and drug development.