U.S. Route 321 is a north-south highway in the United States that stretches approximately 600 miles. It begins in Florida and travels through several states, including Georgia, South Carolina, and North Carolina, before ending in Tennessee. The route serves as a vital connector for various towns and cities along its path. The highway is known for its scenic views, particularly in the Appalachian region, where it passes through mountainous areas. U.S. Route 321 also intersects with other major highways, making it an important route for both local and long-distance travelers.