U.S. Route 220 is a north-south highway that stretches approximately 300 miles through the eastern United States. It begins in the state of Virginia and runs through West Virginia and Pennsylvania, connecting several towns and cities along the way. The route serves as an important corridor for local traffic and commerce. Originally designated in 1926, U.S. Route 220 has undergone various changes and improvements over the years. It intersects with several major highways, including Interstate 81 and U.S. Route 11, enhancing accessibility for travelers and freight transport in the region.