U.S. Route 421 is a major north-south highway in the United States, stretching approximately 940 miles. It begins in the state of North Carolina and travels through several states, including Tennessee, Kentucky, and Indiana, before ending in Michigan City, Indiana. The route serves as an important connector for various towns and cities along its path. Originally established in 1926, U.S. Route 421 has undergone several changes and improvements over the years. It passes through diverse landscapes, including rural areas, mountains, and urban centers. The highway is significant for local economies and tourism, providing access to various attractions and services.