U.S. Route 21 is a north-south highway that stretches approximately 1,400 miles from Cleveland, Ohio to Beaufort, South Carolina. It passes through several states, including West Virginia, Virginia, and North Carolina, serving as a vital connector for various communities along its path. The route is known for its scenic views and historical significance, as it traverses both urban and rural areas. Travelers can experience diverse landscapes, from the Appalachian Mountains to coastal regions, making it a popular choice for road trips and local commutes alike.