U.S. Route 22 is a major east-west highway in the United States, stretching approximately 1,000 miles. It begins in Cincinnati, Ohio and ends in Newark, New Jersey, passing through several states including Indiana, Pennsylvania, and West Virginia. The route serves as an important connector for various cities and towns along its path. Originally established in 1926, U.S. Route 22 has undergone various changes and improvements over the years. It is primarily a two-lane highway in rural areas but expands to multi-lane sections in urban regions. The route is known for its scenic views and accessibility to local attractions.