The "Twelve Links of Dependent Origination" is a key concept in Buddhism that explains how suffering arises and perpetuates in the cycle of samsara, or the cycle of birth, death, and rebirth. These links illustrate the interconnectedness of various factors that lead to suffering, starting with ignorance and ending with aging and death. Each link influences the next, showing how one condition leads to another. The twelve links are: ignorance, volitional formations, consciousness, name and form, six senses, contact, feeling, craving, clinging, becoming, birth, and aging and death. Understanding these links helps individuals recognize the causes of their suffering and the potential for liberation through mindfulness and insight.