Topoisomerase II is an essential enzyme that helps manage the structure of DNA during processes like replication and transcription. It works by cutting both strands of the DNA helix, allowing the strands to unwind and relieve tension caused by supercoiling. After this, it reseals the cuts, restoring the DNA to its original state. This enzyme plays a crucial role in cell division, ensuring that DNA is properly organized and separated into daughter cells. Inhibitors of Topoisomerase II are used in cancer treatments, as they can prevent cancer cells from dividing by disrupting their DNA processes.