Thrombotic Thrombocytopenic Purpura (TTP) is a rare blood disorder characterized by the formation of small blood clots throughout the body's small blood vessels. This leads to a decrease in the number of platelets, which are essential for blood clotting, resulting in symptoms such as bruising, fatigue, and organ damage. TTP can be triggered by various factors, including certain medications, infections, or autoimmune diseases. The condition is often associated with a deficiency of an enzyme called ADAMTS13, which helps regulate blood clotting. When this enzyme is deficient or inhibited, it causes large von Willebrand factor multimers to form, leading to excessive clotting. Prompt diagnosis and treatment, often involving plasma exchange and immunosuppressive therapy, are crucial for improving outcomes in patients with TTP.