TGM1, or transglutaminase 1, is an enzyme that plays a crucial role in the formation of the skin barrier. It helps in the cross-linking of proteins, which is essential for the structure and function of the outermost layer of the skin, known as the stratum corneum. This process is vital for maintaining skin hydration and protecting against environmental damage. Mutations in the TGM1 gene can lead to skin disorders, such as lamellar ichthyosis, a condition characterized by dry, scaly skin. Understanding TGM1's function is important for developing treatments for these genetic skin conditions and improving overall skin health.