Lamellar ichthyosis is a rare genetic skin disorder characterized by dry, scaly skin that resembles fish scales. It is caused by mutations in the TGM1 gene, which plays a crucial role in skin barrier function. Individuals with this condition often experience thickened skin, particularly on the palms and soles, and may have a distinctive appearance at birth, including a collodion membrane. The condition is usually inherited in an autosomal recessive manner, meaning both parents must carry the gene mutation for a child to be affected. While there is no cure, treatments focus on managing symptoms through regular moisturizing and exfoliating to improve skin texture and hydration.