Transglutaminase 1 (TG1) is an enzyme primarily found in the skin, where it plays a crucial role in the formation of the skin barrier. It catalyzes the cross-linking of proteins, which helps to stabilize the structure of the skin and maintain its integrity. This process is essential for proper skin function and protection against environmental factors. Mutations in the gene encoding TG1 can lead to skin disorders, such as ichthyosis vulgaris, characterized by dry, scaly skin. Understanding TG1's function is important for developing treatments for these conditions and improving skin health.