T-Cell Receptor Peptide Library Exchange is a method used in immunology to study how T-Cell Receptors (TCRs) recognize specific peptides presented by Major Histocompatibility Complex (MHC) molecules. This technique involves creating a diverse library of peptides that can bind to TCRs, allowing researchers to identify which peptides are recognized by specific TCRs. By exchanging these peptide libraries, scientists can analyze the interactions between TCRs and peptides, enhancing our understanding of adaptive immunity. This knowledge can lead to advancements in immunotherapy and vaccine development, as it helps identify potential targets for treating diseases like cancer and autoimmune disorders.