"Significant changes" refer to major alterations or transformations that impact a situation, organization, or individual. These changes can occur in various contexts, such as business, technology, or society. They often lead to new opportunities, challenges, or shifts in behavior and can be driven by factors like innovation, policy updates, or cultural shifts. In the context of environmental issues, significant changes might include shifts in climate patterns or the introduction of new regulations aimed at reducing pollution. In healthcare, significant changes could involve the adoption of new medical technologies or changes in patient care practices. Understanding these changes is crucial for adapting and thriving in a dynamic world.