Rare syndromes are medical conditions that affect a small percentage of the population. These syndromes can result from genetic mutations, environmental factors, or unknown causes. Due to their rarity, they often pose challenges in diagnosis and treatment, as healthcare professionals may have limited experience with them. Examples of rare syndromes include Ehlers-Danlos syndrome, which affects connective tissues, and Angelman syndrome, a neurodevelopmental disorder. Research into these syndromes is crucial for understanding their causes and developing effective therapies. Awareness and support for affected individuals and families are essential for improving their quality of life.