Phospholipid Scramblase 3 (PLSCR3) is a protein that plays a crucial role in the movement of phospholipids between the inner and outer layers of cell membranes. This process is important for various cellular functions, including apoptosis, blood coagulation, and cell signaling. PLSCR3 helps maintain membrane asymmetry, which is vital for cell health and communication. PLSCR3 is part of a larger family of scramblases that facilitate the bidirectional transport of phospholipids. It is primarily found in the nucleus and cytoplasm of cells. Dysregulation of PLSCR3 has been linked to several diseases, including cancer and autoimmune disorders, highlighting its significance in cellular processes.