Phospholipid Scramblase 1 (PLSCR1) is a protein that plays a crucial role in the movement of phospholipids between the inner and outer leaflets of cell membranes. This process is essential for various cellular functions, including apoptosis, blood coagulation, and cell signaling. PLSCR1 helps maintain membrane asymmetry, which is vital for cell health and communication. When cells undergo stress or activation, PLSCR1 facilitates the scrambling of phospholipids, leading to the exposure of phosphatidylserine on the outer membrane. This exposure serves as a signal for macrophages to recognize and clear dying cells, thus preventing inflammation and promoting tissue homeostasis.