PMS2, or PMS2 gene, is a human gene that plays a crucial role in the DNA repair process. It is part of the mismatch repair system, which helps maintain genetic stability by correcting errors that occur during DNA replication. Mutations in the PMS2 gene can lead to various health issues, including an increased risk of certain cancers. The PMS2 protein works alongside other proteins in the mismatch repair pathway to identify and repair mismatched DNA bases. Defects in this gene are associated with Lynch syndrome, a hereditary condition that raises the likelihood of developing colorectal and other types of cancer.