The PMS2 gene is a crucial part of the body's DNA repair system. It provides instructions for making a protein that helps fix errors that occur when DNA is copied during cell division. Proper functioning of this gene is essential for maintaining genetic stability and preventing mutations. Mutations in the PMS2 gene can lead to various health issues, including an increased risk of certain cancers, particularly Lynch syndrome. This condition is a hereditary cancer syndrome that affects the body's ability to repair DNA, leading to a higher likelihood of developing colorectal and other types of cancer.