PDGFR-β
PDGFR-β, or Platelet-Derived Growth Factor Receptor Beta, is a protein found on the surface of certain cells. It plays a crucial role in cell growth, development, and healing by binding to its specific growth factors, primarily PDGF-BB. This interaction triggers various cellular processes, including proliferation and migration.
PDGFR-β is particularly important in the formation of blood vessels and the development of connective tissues. Abnormal activation of this receptor has been linked to various diseases, including certain types of cancer and fibrosis, making it a target for therapeutic interventions in these conditions.