PDGFR-α, or Platelet-Derived Growth Factor Receptor Alpha, is a protein found on the surface of certain cells. It plays a crucial role in cell growth, development, and healing by binding to its specific growth factors, which are proteins that stimulate cell division and survival. This receptor is particularly important in processes like wound healing and the formation of blood vessels. When PDGFR-α is activated, it triggers a series of cellular responses that can lead to tissue repair and regeneration. However, abnormal activation of this receptor is associated with various diseases, including certain types of cancer and fibrotic disorders, making it a target for therapeutic interventions.