Receptor Tyrosine Kinases (RTKs) are a class of cell surface receptors that play a crucial role in cellular communication. They are activated by binding to specific ligands, such as growth factors, which leads to their phosphorylation and subsequent activation of various signaling pathways. This process is essential for regulating cell growth, differentiation, and metabolism. Once activated, RTKs initiate a cascade of intracellular signaling events, often involving other proteins that relay the signal within the cell. Dysregulation of RTK signaling can lead to various diseases, including cancer, making them important targets for therapeutic interventions, such as monoclonal antibodies and small molecule inhibitors.