PDGF-BB, or Platelet-Derived Growth Factor-BB, is a protein that plays a crucial role in cell growth, development, and healing. It is part of the PDGF family, which is involved in various biological processes, including the formation of blood vessels and the repair of tissues. PDGF-BB is primarily produced by platelets and is essential for wound healing and tissue regeneration. This growth factor functions by binding to specific receptors on the surface of cells, triggering a series of signals that promote cell division and migration. PDGF-BB is particularly important in the context of fibroblasts, which are cells that help in the formation of connective tissue. Its role in promoting healing makes it a focus of research in regenerative medicine and tissue engineering.