PCSK9 is a protein that plays a crucial role in regulating cholesterol levels in the body. It works by binding to LDL receptors, which are responsible for removing low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol, from the bloodstream. When PCSK9 binds to these receptors, it leads to their degradation, resulting in higher levels of LDL cholesterol in the blood. Research has shown that inhibiting PCSK9 can significantly lower LDL cholesterol levels, which may reduce the risk of cardiovascular diseases. This has led to the development of PCSK9 inhibitors, a new class of medications that help manage cholesterol levels in patients who are at high risk for heart-related issues.