Metalloproteases are a type of enzyme that play a crucial role in breaking down proteins. They require metal ions, such as zinc or manganese, to function effectively. These enzymes are involved in various biological processes, including tissue remodeling, wound healing, and the immune response. These enzymes are found in many organisms, from bacteria to humans, and are important in both normal physiological functions and disease states. For example, matrix metalloproteinases (MMPs) are a subgroup of metalloproteases that help degrade components of the extracellular matrix, which is vital for cell migration and tissue repair.