Liddle syndrome is a rare genetic disorder that affects the kidneys' ability to regulate sodium and potassium levels. It is caused by mutations in specific genes that lead to increased activity of sodium channels in the renal tubules, resulting in excessive sodium reabsorption. This can cause high blood pressure and low potassium levels, known as hypokalemia. Symptoms of Liddle syndrome may include hypertension, muscle weakness, and fatigue due to low potassium. Diagnosis typically involves genetic testing and blood tests to assess electrolyte levels. Treatment often focuses on managing blood pressure and correcting electrolyte imbalances, sometimes using medications like potassium-sparing diuretics.