IDH2, or isocitrate dehydrogenase 2, is an enzyme found in the mitochondria of cells. It plays a crucial role in the citric acid cycle, which is essential for energy production. IDH2 helps convert isocitrate into alpha-ketoglutarate while producing NADPH, a molecule important for cellular processes. Mutations in the IDH2 gene can lead to various health issues, including certain types of cancer, such as acute myeloid leukemia (AML). These mutations can alter the enzyme's function, leading to the accumulation of oncometabolites, which can promote tumor growth and progression. Understanding IDH2 is important for developing targeted therapies.