Isocitrate Dehydrogenase is an important enzyme in the citric acid cycle, which is a key metabolic pathway that generates energy in cells. It catalyzes the conversion of isocitrate to alpha-ketoglutarate, producing NADH and CO2 in the process. This reaction is crucial for cellular respiration, as it helps to release energy stored in carbohydrates, fats, and proteins. There are different forms of isocitrate dehydrogenase, including IDH1 and IDH2, which are found in various tissues and have distinct roles. Mutations in these enzymes can lead to metabolic disorders and are also associated with certain types of cancer, highlighting their significance in both health and disease.