The House of Guise was a powerful noble family in France during the 16th century. They played a significant role in the French Wars of Religion, which were conflicts between Catholics and Protestants. The family was known for its strong Catholic beliefs and political ambitions, often opposing the House of Bourbon. Founded by Claude de Guise, the house produced several influential figures, including Henry I, Duke of Guise, who became a prominent leader in the Catholic League. The family's influence waned after the assassination of Henry III in 1588, leading to a decline in their power and prominence in French politics.