The House of Mecklenburg-Strelitz was a German noble family that originated in the region of Mecklenburg. Established in the 18th century, it became prominent when Duke Charles II of Mecklenburg-Strelitz ascended to power. The family is known for its connections to various European royal houses through marriage. Members of the house played significant roles in the politics of Germany and Europe. Notably, Queen Charlotte, wife of King George III of Great Britain, was a member of this house. The family's influence waned over time, but their legacy remains in the history of European nobility.