The House of Mayenne was a noble family in France, part of the larger House of Lorraine. It emerged in the late 16th century and played a significant role in the political landscape of France during the Wars of Religion. The family was known for its alliances with other noble houses and its involvement in various conflicts. The most notable member was Henri de Mayenne, who was a leader of the Catholic League. The house's influence waned after the 17th century, but it left a lasting legacy in French history through its contributions to the nobility and regional governance.