The House of Mecklenburg-Strelitz was a German noble family that originated in the 18th century. It was a branch of the larger House of Mecklenburg and ruled the Duchy of Mecklenburg-Strelitz, located in northern Germany. The family gained prominence when Charlotte of Mecklenburg-Strelitz married King George III of the United Kingdom in 1761, becoming Queen Consort. The dynasty produced several notable figures and played a significant role in European history. Members of the House of Mecklenburg-Strelitz held various titles and positions, including Grand Dukes and Dukes, and were involved in the political affairs of their time, particularly during the German Confederation.