The Guise Family, also known as the House of Guise, was a prominent noble family in France during the Renaissance period. They were known for their significant political influence and their role in the French Wars of Religion. The family produced several important figures, including Henry I, Duke of Guise, who was a key leader of the Catholic League. The Guise Family was originally from Lorraine and rose to power in the 16th century. Their rivalry with the Bourbon family and involvement in various conflicts shaped the political landscape of France. The family's influence waned after the death of Henry I in 1588, but their legacy remains a notable part of French history.