The House of Guise was a prominent noble family in France during the 16th and 17th centuries. They played a significant role in the French Wars of Religion, aligning with the Catholic League against the Protestant Huguenots. The family was known for its political power and influence, particularly through figures like Henry I, Duke of Guise. The Guise family was also involved in various royal intrigues and conflicts, often seeking to expand their influence. Their rivalry with the House of Bourbon and other noble families contributed to the complex political landscape of France during this tumultuous period.