The Duke of Guise was a prominent French nobleman in the 16th century, known for his role in the French Wars of Religion. Born in 1519, he was a member of the powerful House of Guise, which was a leading family in the Catholic faction during the conflicts between Catholics and Huguenots (Protestants) in France. He played a significant role in the political and military struggles of his time, notably leading troops in several battles. The Duke was also involved in the assassination of Henri III, which ultimately led to his own death in 1588, marking a pivotal moment in the ongoing religious and political turmoil in France.