The Glyoxalase System is a biochemical pathway that helps detoxify harmful compounds in the body, particularly glyoxal and methylglyoxal. These compounds can form as byproducts of metabolism and are known to cause cellular damage. The system primarily consists of two enzymes: glyoxalase I and glyoxalase II, which work together to convert these toxic substances into less harmful molecules. This detoxification process is crucial for maintaining cellular health and preventing complications associated with high levels of reactive carbonyl species. By efficiently processing these harmful compounds, the Glyoxalase System plays a significant role in protecting cells from oxidative stress and related diseases, including diabetes and neurodegenerative disorders.