The Despenser War (1321-1326) was a conflict in England between supporters of the powerful Despenser family and those opposing their influence, particularly the faction led by Hugh Despenser the Younger and Isabella of France. The war arose from political tensions and the growing resentment against the Despensers, who were seen as corrupt and overly ambitious. The conflict escalated when Isabella, the wife of King Edward II, allied with Roger Mortimer to challenge the Despensers' power. The war ultimately led to the downfall of the Despenser family, the capture of Hugh Despenser the Younger, and significant changes in the English monarchy.