Congenital Absence of Uterus, also known as Mayer-Rokitansky-Küster-Hauser syndrome, is a rare condition where a female is born without a uterus. This condition can occur alongside other reproductive tract anomalies and may affect the development of the vagina and ovaries. Women with this condition typically have normal external genitalia and secondary sexual characteristics but may face challenges with menstruation and fertility. Diagnosis often occurs during adolescence when menstruation does not begin. Treatment options may include surgical interventions to create a functional vagina or assisted reproductive technologies for those wishing to conceive. Psychological support is also important for affected individuals to address emotional and social implications.