Coagulation Factor VIII is a crucial protein in the blood clotting process. It works by helping platelets stick together and form a stable clot, which is essential for stopping bleeding. Deficiency or dysfunction of Factor VIII can lead to bleeding disorders, the most common being Hemophilia A. Factor VIII is produced primarily in the liver and circulates in the bloodstream in an inactive form. When a blood vessel is injured, it is activated and interacts with other proteins, including Factor IX, to initiate the clotting cascade. This process is vital for wound healing and maintaining hemostasis.