Ammonia disorders refer to conditions where there is an abnormal level of ammonia in the blood. This can occur due to liver dysfunction, where the liver fails to convert ammonia into urea, leading to its accumulation. High ammonia levels can cause symptoms such as confusion, lethargy, and in severe cases, coma. These disorders are often associated with liver diseases like cirrhosis or hepatitis, as well as genetic conditions affecting urea cycle metabolism. Diagnosis typically involves blood tests to measure ammonia levels, and treatment may include medications, dietary changes, or in severe cases, liver transplantation.