ADAMTS-4 is an enzyme that belongs to the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family. It plays a crucial role in the breakdown of extracellular matrix components, particularly aggrecan, which is a key protein in cartilage. This process is important for maintaining healthy joint function and is involved in various physiological and pathological conditions. In addition to its role in cartilage degradation, ADAMTS-4 is also implicated in several diseases, including osteoarthritis and rheumatoid arthritis. By regulating the turnover of proteoglycans and other matrix proteins, it influences tissue remodeling and repair. Understanding ADAMTS-4 can help in developing targeted therapies for joint-related disorders.