ADAMTS-13 is a protein that plays a crucial role in blood clotting. It is responsible for breaking down a large protein called von Willebrand factor, which helps platelets stick together to form clots. Proper functioning of ADAMTS-13 ensures that blood clots do not become excessively large, which can lead to complications. When ADAMTS-13 is deficient or dysfunctional, it can result in a condition known as Thrombotic Thrombocytopenic Purpura (TTP). This disorder is characterized by the formation of small blood clots throughout the body, leading to a range of serious health issues, including organ damage and low platelet counts.